Modelling and Simulation Engineer
CMAC is a world-leading medicines manufacturing research centre based in the Technology and Innovation Centre (TIC) at the University of Strathclyde. The centre works closely with leading pharmaceutical companies to transform the way that medicines are developed and made and support a portfolio of research programmes to deliver our shared vision.
Applications are invited for a Modelling and Simulation Engineer (Grade 7) to work in the EPSRC MediForge: Industry 5.0 Medicines Manufacturing Research Hub being delivered by CMAC. MediForge comprises a multidisciplinary team of academics and researchers located across five leading UK Universities (Strathclyde, Leeds, Sheffield, Imperial College and Glasgow School of Art) providing a platform for collaborative research, training and knowledge exchange in the area of advanced pharmaceutical manufacturing.
MediForge was awarded under EPSRC’s Manufacturing Hubs for A Sustainable Future (Round 2) call and aims to develop a systems level approach for predictive design of sustainable, resilient and human-centric future medicines manufacturing covering multiple stages across drug substance and drug product processing. The Hub has a large and vibrant programme with key Industry partners including AZ, Chiesi, Lilly, Pfizer, Roche, Sanofi, Takeda and UCB with a broad range of technology companies. The Hub also benefits from significant recent capital investments through our £33M UK RPIF Data Lab partnership creating a world class suite of advanced processing, automation, analysis, digital technologies and computational infrastructure to support MediForge research.
A key goal of Platform 1 is to deliver an integrated cyberphysical research infrastructure (CPRI) that connects comprehensive data generated from a suite of material sparing, self-driving DataFactory platforms for the target processing steps into a novel medicines manufacturing research data fabric. This will integrate with the end-to-end digital twin in Platform 2 to enable whole process design and optimisation for quality and sustainability.
Designs will be evaluated from data generated by the MediForge MicroFactory Test Bed (Platform 3) spanning drug substance (synthesis, crystallisation, isolation) and drug product (feeding, blending, compaction) unit operations. The Modelling and Simulation Engineer, supporting Platforms I and 2 reports to the Project Co-lead and will work closely with a multidisciplinary team of academics, PDRAs and PhDs. Within the multidisciplinary team this post will support the acquisition and processing of data, and the building of physics-based (mechanistic), data-driven and/or hybrid models across all key primary processing (drug substance) steps (e.g. synthesis, work-up, crystallisation, filtration, washing and drying). The post holder will be responsible for developing new or implementing existing models, and the parameterisation or training of these models for specific cases, reporting on project progress and contribute to the preparation of research papers arising from these and related studies in the group.
You should hold a HNC/HND in a relevant discipline (e.g. Chemical or Pharmaceutical Engineering) or a related area with significant, experience in process systems modelling. Experience in drug substance manufacturing processes would also be beneficial.
To apply, please go to the Strathclyde webpages. Closing date - 10.02.2025