Launch of CMAC-Huxley Bertram Partnership to Support Compaction Simulation Research and Services
Launch of CMAC-Huxley Bertram Partnership to Support Compaction Simulation Research and Services
CMAC are pleased to announce that following the recent establishment of our new Compaction Simulation Pilot Test Facility that we can now offer Compaction Simulation Research Services through our National Facility Team. This is supported by a new partnership between Huxley Bertram and the CMAC Future Manufacturing Research Hub at the University of Strathclyde (Glasgow, UK). An HB50 Huxley Bertram Compaction Simulator specified with instrumented dies and innovative process analytics for in situ measurements using terahertz spectroscopy has recently been installed in CMAC’s facilities. Compaction simulation research at CMAC is being led by academics and scientists expert in compaction simulation with cutting edge application and engineering support provided by Huxley Bertram’s Cambridge-based staff.
CMAC National Research Facility was established through investment from UK-RPIF, Wolfson Foundation, SFC, University of Strathclyde and our industry partners and is the only international academic facility to receive a coveted ISPE 'Facility of the Year Award'. The first in world integrated compaction simulator-terahertz system was made possible by support from EPSRC which is housed alongside suites of state-of-the-art continuous processing equipment, extensive process analytics, advanced automation & control and advanced characterisation techniques for pharmaceutical systems. The facility has a dedicated support team which offers consultancy, research services and collaboration support for both academic & industrial research & development.
Compaction Simulation Services
Several levels of compaction simulation research and development work are available on a contract basis:
Material characterisation and advanced compaction studies of active pharmaceutical ingredients (APIs), excipients and blends.
Routine powder characterisation, constitutive analyses (axial stress/strain).
Compactibility/compressibility/tabletability studies.
Radial analyses (instrumented dies).
Advanced compaction studies: radial analyses, frictionless ejection.
Die compaction (rotary press) roll compaction and capsule tamping.
High-fidelity rotary presses simulation, including hybrid MODUL simulations.
Material-sparing formulation and process development.
Material-sparing replication of direct compression & dry granulation processes (DC/DG).
Formulation assistance and optimisation including lubrication studies.
Formulation design, development and scale-up.
Process understanding development:
Compaction understanding and materials science by pairing compaction simulation with exceptional advanced characterisation techniques: X-ray computed nanotomography, time-of-flight secondary ion mass spectrometry, etc.
Compaction thermodynamics, in-die temperature evolution.
Microstructure analysis using terahertz spectroscopy and X-ray computed nanotomography.
Troubleshooting of clinical and commercial die compaction processes
Contact us for more information
CMAC Future Manufacturing Research Hub: cmac-national-facility@strath.ac.uk
For other simulation services inquiries contact Huxley Bertram: Martin Bennett, martinwbennett@huxleybertram.com