ADDoPT
The ADDoPT (Advanced Digital Design of Pharmaceutical Therapeutics) project is addressing the pharmaceutical industry’s desire to deliver medicines more e ectively to patients. ADDoPT is developing and implementing advanced digital design techniques that eliminate non-viable drug candidate formulations as early as possible, streamlining design, development and manufacturing processes.
CMAC & AstraZeneca Digital Design Accelerator Programme
“We are pleased to lead this exciting collaboration between end users, technology providers and academic research in order to deliver a transformational platform with the potential to accelerate development of new medicines for patients. Through adoption of digital tools we can build in operational excellence right from the start of pharmaceutical development, improve product robustness, and drive more efficient manufacturing processes. Thereby delivering more medicines to more patients, more quickly”.
Sophie Bailes, Associate Director in Digital Transformation at AstraZeneca
PSE & CMAC
CMAC & Process Systems Enterprise Model-based Digitalisation Framework Development for Continuous Manufacturing Processes
This Innovate UK Knowledge Transfer Partnership project is a collaboration between the University of She eld and Process Systems Enterprise (now a Siemens business). The aim of the project was to develop a systematic methodology for the application of a mechanistic-based digitalization framework, to enable pharmaceutical and other industries to effectively and efficiently design and implement continuous manufacturing processes.
The project has lead to the development of mechanistic models for continuous pharmaceutical manufacturing, successfully implemented in gPROMS Formulated Products so ware and validated using the continuous pharmaceutical manufacturing facilities at the University of Sheffield.
CMAC & Process Systems
CMAC & Process Systems Enterprise Industrial Workflows for the Application of a User-friendly Mechanistic Modelling Toolkit This KTP project is a joint-venture between CMAC and PSE aimed at:
Creating industrial workflows for the application of a user-friendly mechanistic modelling toolkit for active ingredient manufacture
Delivering step-change improvements in functionality and usability of gPROMS Formulated Products
Developing an enhanced tool accessible to a wide range of users – from non-expert operators/users to skilled modellers/ engineers
